Which significant industrial region in the central United States forms borders between five states?

The significant industrial region in the central United States that forms borders between five states is indeed associated with Ohio. Ohio is a key player in the manufacturing sector, particularly known for its contributions in industries such as automotive, steel, and aerospace. The state's strategic location allows it to interact economically and industrially with neighboring states, making it a significant hub in the region.

Ohio borders Pennsylvania, West Virginia, Kentucky, Indiana, and Michigan, making it a central point of industrial activity. The presence of major cities like Cleveland, Cincinnati, and Columbus further enhances its role as a central industrial region. This geographic positioning not only facilitates transportation and trade but also supports a diverse industrial base that extends its influence to the surrounding states.

Other choices do not align with this description as closely; for instance, Missouri is significant as well but does not border as many states as Ohio. Mississippi primarily represents a different regional focus, leaning more towards agriculture and river-based economies rather than a robust industrial center. The Mackenzie region pertains to a broader geographical area in Canada and is not central to the U.S. industrial narrative. Thus, Ohio stands out for the reasons highlighted.